NO PRESCRIPTION REQUIRED! Fit America’s newest weight loss supplement has taken the best of three clinically proven ingredients, LeptiCore, 7-Keto DHEA and CLA, and married them into a powerful and effective weight loss product.
LeptiCore® – Clinically Proven to Promote Weight Loss and Improve Body Size
LeptiCore® heightens the proprietary status of a wide variety of product applications including: weight management, metabolic wellness/balance, blood sugar balance, and cardiovascular health.
LeptiCore® is a patent-pending, multifunctional complex of plant-based polysaccharides, esterified fatty acids, pomegranate extract, beta-carotene, and blue-green algae.These complementary ingredients provide multiple mechanisms of action to support Metabolic Wellness and overall health.
7-Keto DHEA®~
The Fat-Burning Metabolite of DHEA (dehydroepiandrosterone), is a hormone that’s naturally produced by the adrenal glands.
CLA – Conjugated linoleic acid
CLA helps reduce body fat deposits and improve immune function. It refers to a group of chemicals found in fatty acid / linoleic acid. Dairy products and beef are the major dietary sources, although are generally not present in levels that assist weight loss.Conjugated linoleic acid is used for cancer, “hardening of the arteries” (atherosclerosis), obesity, weight loss caused by chronic disease, bodybuilding, and limits food allergy reactions.
Please note that all weight and fat loss messages are based upon combining an efficacious dose of ingredient daily with Fit America’s program of sensible eating and moderate exercise.
Lepticore ® is a trademark of Gateway Health Alliances, Inc and is protected under US Patent 6,899,892 and patents pending.
Dosage:
Take 2 capsules twice daily. First dosage should be 15 minutes prior to a meal. Second dosage should be taken before 6:00 PM.
Science: LeptiCore® – Clinically Proven to Promote Weight Loss and Improve Body Size
It heightens the proprietary status of a wide variety of product applications including: weight management, metabolic wellness/balance, blood sugar balance, and cardiovascular health.
LeptiCore® is a patent-pending, multifunctional complex of plant-based polysaccharides, esterified fatty acids, pomegranate extract, beta-carotene, and blue-green algae. These complementary ingredients provide multiple mechanisms of action to support Metabolic Wellness and overall health.
Promoting healthy weight management is vital to achieving metabolic wellness because over weight and obese individuals are much more likely to develop metabolic syndrome compared to those with normal weight according to the Third National Health and Nutrition Examination Survey. A wide body of scientific research has shown that weight loss leads to a significant reduction in risk factors for metabolic syndrome. With this in mind, developers of LeptiCore® created a unique complex of ingredients that, when taken as directed, leads to a significant reduction in weight and improvement in body size.
LeptiCore® was formulated to promote healthy weight management through the correction of leptin resistance, which helps support increased satiety, loss of appetite, blood sugar balance, and thermogenesis. These mechanisms of action led to significant reductions in body weight, stored body fat, and waist and hip size in a randomized, double-blind, placebo-controlled clinical trial involving 92 subjects who took LeptiCore twice daily for 8 weeks.
LeptiCore® Enhances Leptin Function
The primary mechanism utilized in LeptiCore® to support healthy weight management
is through enhancement of leptin function. Leptin is a hormone produced by fat cells that regulates body weight. Normally, in healthy weight individuals, leptin crosses the blood-brain barrier to influence brain activity in the areas of satiety and appetite suppression. Leptin also boosts glycemic control and metabolism.In overweight and obese people, leptin production is high, yet its function is diminished because the body becomes resistant to it. Leptin resistance results inincreased appetite, poor blood sugar balance, and slower metabolism. LeptiCore®is clinically proven to lower leptin resistance and improve leptin function. This is a primary factor in LeptiCore’s ability to promote weight and fat reduction.
LeptiCore® Addresses Additional Metabolic Risk Factors, Enhances Mood and Increases Satiety by Raising Serotonin Levels
LeptiCore® contains two antioxidants, pomegranate extract and beta-carotene,that address other risk factors of metabolic syndrome including inflammation and elevated blood lipids. These risk factors, which also affect cardiovascular health, reach dangerous levels in overweight and obese people. LeptiCore® is clinically proven to reduce C-reactive protein (a marker of systemic inflammation that is inflated in people with metabolic syndrome), lower LDL (bad) cholesterol, and raise HDL (good) cholesterol.
In addition,LeptiCore® enhances mood because the blue-green algae it is formulated with contains phenylethylamine (PEA). Studies have shown that PEA (found in dark chocolate) raises levels of serotonin, a neurotransmitter in the brain that is associated with enhanced mood. In a recent clinical trial, serotonin levels rose significantly in subjects who took LeptiCore® twice daily. In addition, serotonin suppresses appetite by a mechanism that is complementary to that of leptin,further contributing to LeptiCore’s weight management and satiety properties.In the same double-blind, placebo-controlled clinical trial mentioned previously, serotonin levels increased by 28.5% in subjects takingLeptiCore®.
All claims are in accordance with the requirements of the Dietary Supplement Health and Education Act of 1994 and have been submitted to the Food and Drug Administration accordingly.
Weight Loss/Weight Management Claims
Satiety/Appetite Control Claims
Thermogenesis Claims
Safety & Stability
LeptiCore® has an exceptional safety and stability profile. In an 8 week long human clinical trial involving 92 subjects, LeptiCore® was well tolerated with no dropouts. Additionally, LeptiCore® is supported by both sub-acute and LD50 oral toxicity studies confirming its safety. Accelerated stability studies confirm that LeptiCore® has a shelf life of two years.
7-KETO®– DHEA (dehydroepiandrosterone),
DHEA is a hormone that’s naturally produced by the adrenal glands. Levels of DHEA and 7 KETO naturally drop after age 30, which can negatively affect weight maintenance. Unlike other DHEA, 7-Keto will not metabolize into the sex hormones (estrogen and testosterone) as “plain” DHEA will.
7-Keto® DHEA ~ The Fat-Burning Metabolite of DHEA
While many anti-aging enthusiasts are familiar with the hormone DHEA (dehydroepiandrosterone), far fewer are likely to be aware of its metabolite, 7-Keto DHEA, which is responsible for many of DHEA’s beneficial actions.
Scientists have documented DHEA’s wide-ranging benefits in numerous clinical studies. DHEA helps to retard the effects of aging and promotes enhanced longevity, exerting a multitude of effects through its conversion to some 150 metabolites, each with unique actions within the body.
One of the most important of these is 7-Keto DHEA (commonly referred to as 7-Keto), a hormone metabolite that can safely boost immune function and help reduce body fat. Unlike DHEA, however, 7-Keto does not convert to estrogen and testosterone. Because DHEA and 7-Keto have separate and unique functions and properties, it is important to understand the differences between these two popular dietary supplements.
1 – Clinically-Proven 200% More Weight Loss Than Diet and Exercise Alone
Randomized, Double-Blind, Placebo-Controlled Study of 3-Acetyl-7-Oxo-Dehydroepiandrosterone in Health Over Weight Adults. CurrTher Res2000;61(7):435-442.The Effect of 7-Keto™ Naturalean ™ on Weight Loss: A Randomized, Double Blind, Placebo Controlled Trial. CurrTher Res 2002;63(4):263-272
2 – Majority of Weight Loss is Fat Loss
Randomized, Double-Blind, Placebo-Controlled Clinical Trial to Evaluate the Thermogenic and Body Composition Effects of 3-Acetyl-7-Oxo-Dehydroepiandrosterone (7-Keto™) Clinical Study Final Report, Humanetics Archives. A Randomized, Double-Blind, Placebo-Controlled Study of 3-Acetyl-7-Oxo-Dehydroepiandrosterone in Health Over Weight Adults. CurrTher Res2000;61(7):435-442.The Effect of 7-Keto™ Naturalean ™ on Weight Loss: A Randomized, Double Blind, Placebo Controlled Trial. CurrTher Res 2002;63(4):263-272.
3 – Promotes Weight Loss Without Use of Stimulants
Randomized, Double-Blind, Placebo-Controlled Study of 3-Acetyl-7-Oxo-Dehydroepiandrosterone in Health Over Weight Adults. CurrTher Res2000;61(7):435-442.The Effect of 7-Keto™ Naturalean ™ on Weight Loss: A Randomized, Double Blind, Placebo Controlled Trial. CurrTher Res 2002;63(4):263-272.
4 –Awarded U.S. Patent for Metabolic Rate Increase and Weight Loss
United States Patent Number 7,199,116
5 – Augments What the Body Naturally Produces
Ergosteroids II: Biologically Active Metabolites and Synthetic Derivatives of Dehydroepiandrosterone. Steroids 1998;63:158-165.Induction of Thermogenic Enzymes by DHEA and Its Metabolites. In: Bellino F, Daynes RA, Hornsby PJ, Lavrin DH, Nestler JE,eds Dehydroepiandrosterone (DHEA) and Aging. New York:New York Academy of Sciences; 1995:171-179.Studies in Steroid Metabolism: Isolation and Characterization of New Urinary Studies. J BiolChem1954;210:129-137.
6 – Clinically-Proven Weight and Fat Loss
Randomized, Double-Blind, Placebo-Controlled Study of 3-Acetyl-7-Oxo-Dehydroepiandrosterone in Health Over Weight Adults. CurrTher Res2000;61(7):435-442.The Effect of 7-Keto™ Naturalean ™ on Weight Loss: A Randomized, Double Blind, Placebo Controlled Trial. CurrTher Res 2002;63(4):263-272.
7 – Safe, When Used As Directed
Safety and pharmacokinetic study with escalating doses of 3-acetyl-7-oxo-dehydroepiandrosterone in healthy male volunteers.Clin Invest Med 2000;23(5):300-310A Randomized, Double-Blind, Placebo-Controlled Study of 3-Acetyl-7-Oxo-Dehydroepiandrosterone in Health Over Weight Adults. CurrTher Res2000;61(7):435-442.Humanetics Affidavit, Humanetics Archives.
8 – Activates 3 Thermogenic Enzymes – Promotes Thermogenesis by Burning Fat
Ergosteroids II: Biologically Active Metabolites and Synthetic Derivatives of Dehydroepiandrosterone. Steroids 1998;63:158-165.The Effects of the Ergosteroid 7-oxo-dehydroepiandrosterone on Mitochondrial Membrane Potential: Possible Relationship to Thermogenesis, Arch BiochemBiophys1997;341:122-128.A Randomized, Double-Blind, Placebo-Controlled Study of 3-Acetyl-7-Oxo-Dehydroepiandrosterone in Health Over Weight Adults. CurrTher Res2000;61(7):435-442.
9 – Natural “7-Keto” Levels Decline With Age
Marenich LP. Secretion of Testosterone, Epitestosterone, Androstenedione, and 7-Keto-Dehydroepiandrosterone in Healthy Men of Different Ages.ProbEndokrino. 1979;25(4):28-31.
10 – Increases Metabolism 5.4 % Without Use of Stimulants
HUM5007, a novel combination of thermogenic compounds, and3-acetyl-7-oxo-dehydroepiandrosterone: each increases the resting metabolic rate of overweight adults. J NutrBiochem2007;18:629-634
The Primary Thermogenic Hormone
7-Keto produces fat loss through the process of thermogenesis. This term refers to the creation of heat, which is one of the forms of energy produced when the body’s cells metabolize the food we eat. Greater amounts of thermogenesis boost the body’s metabolic rate which increases the conversion of stored fat into energy.
7-Keto enhances the activity of three thermogenic enzymes that stimulate fatty acid oxidation in the liver. These thermogenic-enhancing enzymes are fatty acyl CoA oxidase, malic enzyme, and glycerol-3-phosphate dehydrogenase (6,10-12). These enzymes drive the liver cells to burn fatty acids for energy, which causes a lowering of triglycerides in the liver.
Supplementation with 7-Keto has a dramatic effect on boosting levels of these thermogenic-enhancing enzymes. Studies found that 7-Keto significantly increased the activity of these fat burning enzymes. A study published in Current Therapeutic Research revealed just how effective 7-Keto is in inducing fat loss. In this randomized, double-blind, placebo-controlled study, 30 overweight adults (28 women and 2 men) were divided into two groups. Group 1 received 100 mg of 7-Keto twice daily for eight weeks, while group 2 took a matching placebo capsule. All subjects participated in an exercise program three times a week that consisted of 50 minutes of aerobic and non-aerobic cross training under the supervision of an exercise physiologist. In addition, each subject was instructed by a registered dietitian to follow an 1800-calorie-a-day diet. The subjects underwent testing for blood chemistry, body composition, blood pressure, and dietary analysis at baseline and at weeks four and eight.
The researchers found that the 7-Keto group lost 200% more body weight compared to the placebo group—6.3 versus 2.1 pounds. The 7-Keto group also lost a greater percentage of body fat compared to the placebo group—1.8% versus 0.57%.13 Compared to the placebo group, the 7-Keto group saw a significant increase in thyroid hormone activity that targets fat- burning genes in the mitochondria and adipose tissue. No adverse effects were reported. The results show that 7-Keto can significantly and safely reduce body weight and body fat when combined with exercise and a reduced-calorie diet. This is due to the greatly increased levels of fat-burning enzymes in the liver as well as the elevation of thyroid hormone. These beneficial changes are known to boost basal metabolic rate, making it easier to shed excess pounds. Supplementation with 7-Keto can therefore help reverse the decline in metabolic rate that makes it so easy to put on weight as we age. Unlike caffeine and ephedrine, 7-Keto does not have a central nervous system stimulating effect caused by nor-adrenalin release, nor does 7-Keto increase heart rate or blood pressure.
Fast-Acting and Safe
The term 7-Keto is, in fact, a brand name for the chemical compound 3-acetyl-7-oxo-dehydroepiandros-terone, a naturally occurring metabolite primarily produced in the adrenal glands and skin (though some production occurs in the brain as well). It was first discovered in 1958, when it was found in urine. Human blood levels of 7-Keto tend to follow the same course over time as those of DHEA, rising until about the age of 20 and then slowly descending beginning around the age of 30. Urinary excretion studies show that average blood concentrations of 7-Keto decline nearly 50% by age 50. This reduction in 7-Keto levels is partially responsible for the increases in body fat and total body weight often seen in older people.
Another benefit to 7-Keto is that it does not convert to estrogen or testosterone.This makes 7-Keto a safe alternative for persons with hormone-sensitive cancers, for whom regular DHEA may be too risky.
Immune-Boosting Properties
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Aging is associated with a decline in immune system response, with often-dramatic reductions in immune function. This leads to increased susceptibility to infections. For example, people with age-related declines in cellular immunity have an impaired response to influenza vaccine, making them more susceptible to catching the flu, even if they have received a flu shot. A study at the Minnesota Applied Research Center and the Geriatric Research Education and Clinical Center in Minneapolis found that four weeks of 7-Keto supplementation improved immune function in elderly men and women.In this randomized, double-blind, placebo-controlled study, 22 women and 20 men over the age of 65 took 100 mg of 7-Keto twice daily or a placebo of identical shape and size. Patients in the 7-Keto group had a significant decrease in immune suppressor cells and a significant increase in immune helper cells. The 7-Keto group also saw reductions in diastolic blood pressure and an increase in neutrophils, the first white blood cells to respond to infection. The scientists concluded that 7-Keto was well tolerated and had no serious adverse effects. |
A Czech research team discovered that 7-Keto can counteract the effect of circulating glucocorticoids, such as cortisol, which often rise with age and can suppress immune function.This study was performed in vitro on the spleen lymphocytes of mice, which were exposed to an immune-suppressing drug. Without 7-Keto, the drug produced dramatic reductions in spleen lymphocyte levels. However, when 7-Keto was added, cell viability more than doubled and a measure of primary immune response rose by 150%.
A study at the Chinese Academy of Medical Sciences in Beijing confirms the immune-boosting properties of 7-Keto.Scientists exposed mice with compromised immune systems to chronic mild stress for four weeks. The traumatic regimen decreased their white blood cell proliferative response and produced other abnormalities in immune function. Additionally, levels of thyroid hormones decreased. However, when the mice were given
7-Keto at a dose of 15 mg/kg of body weight, their blood cell proliferative response and natural killer cell activity were dramatically enhanced. The levels of thyroid hormone also returned to normal.
Cholesterol Reduction and Other Benefits
Scientists have known for some time that DHEA supplementation can decrease blood cholesterol levels.The question then became which DHEA metabolite or metabolites are responsible for this action. A study at the Institute of Endocrinology in Prague, Czech Republic, revealed that 7-Keto contributes to this cholesterol-lowering activity.Ten volunteers aged 27 to 72 years applied a gel containing 25 mg of 7-Keto to their abdominal skin for five consecutive days.
While the subjects’ reduction in total cholesterol was of only borderline significance, very beneficial changes occurred in cholesterol composition. Beneficial HDL (high-density lipoprotein) rose significantly, even though harmful LDL (low-density lipoprotein) was only slightly diminished. These changes produced a strong improvement in the atherogenic index, which measures the risk of cardiovascular disease. A significant rise in beneficial apolipo-protein A-1, a protector of cardiovascular health, also occurred. These findings indicate that 7-Keto has cholesterol-lowering effects at a dosage that is even lower than that required to achieve the same effects with DHEA.
A study with mice suggests that 7-Keto can boost memory as well.In this experiment, researchers at the University of Wisconsin in Madison trained young mice in the use of a water maze. They found that a single injection of 7-Keto (at 24 mg/kg of body weight) reversed experimentally induced memory loss. The scientists then fed 7-Keto or DHEA to old mice that had learned the maze. They discovered that memory of the water-maze training was retained during a four-week test period in the mice receiving 7-Keto, but not in those treated with DHEA.17
7-Keto may also provide benefits for people with Raynaud’s syndrome, a condition marked by cold, painful fingers and toes. Medical researchers believe that Raynaud’s represents an abnormal response to cold by blood vessels. A paper published in Medical Hypotheses suggests that 7-Ketomay be helpful in preventing primary Raynaud’s attacks by increasing the basal metabolic rate.Given what is known about 7-Keto’s ability to boost levels of thyroid hormone T3, this hypothesis seems reasonable. Further study is warranted.
Combination DHEA and 7-Keto Therapy
Because of the overwhelming scientific literature supporting the benefits of DHEA supplementation in older people, Life Extension has advocated DHEA replacement therapy since 1981. While this has been a dramatic step forward for many people, the newest research shows that additional benefits can be obtained through a combination of DHEA and 7-Keto therapy.
“Co-supplementation with these hormones can be a very important part of hormone-restorative therapy,” explains Dr. Dzugan. “There are times when the use of regular DHEA can boost estrogen and testosterone concentrations to appropriate levels but still not be enough to put DHEA in the optimal range. Supplementation with 7-Keto can permit additional progress in optimizing immune function, cholesterol reduction, weight loss, and memory enhancement without raising these ‘downstream’ hormones, estrogen and testosterone, to an inappropriate degree.
“Also, women sometimes experience hair loss or growth in facial hair when they take large amounts of DHEA due to its conversion to testosterone. The use of 7-Keto and a smaller, more suitable intake of DHEA can eliminate this problem while still giving them many of DHEA’s benefits, which in reality are due to its 7-Keto metabolite. Moreover, DHEA supplementation is contraindicated for hormone-sensitive cancers such as prostate cancer and many breast cancers. In these instances, dosing with 7-Keto is a viable alternative.”
As shown earlier , average blood levels of 7-Keto decline with age. This reduction is responsible for some of the negative changes that occur during our mature years. As a result, 7-Keto supplementation becomes increasingly important with age.
7-Keto should be taken twice daily for best results – once in the morning, when the body’s natural production peaks and again before dinner. Twice daily dosing will allow you to achieve steady state levels in the blood, which maximizes efficacy and speed of onset. This also ensures that more plentiful levels of this hormone will be available consistent with the body’s natural cycle.
Because 7-Keto is a natural hormone metabolite and is easily assimilated, it can be taken with a meal or on an empty stomach. Consistent daily dosing is important to ensure a stable level of 7-Keto in the bloodstream.
With all of the newly recognized benefits of 7-Keto, this workhorse metabolite is sure to become a standard part of hormone replacement therapy in the future. By offering many of the advantages of DHEA supplementation without conversion to estrogen and testosterone, 7-Keto affords older adults the opportunity to further promote their health and longevity even when their levels of the so-called “downstream” hormones are already optimal. Moreover, considering 7-Keto’s demonstrated ability to improve body composition, it is highly likely that this DHEA metabolite will become a staple supplement for many aging adults. After all, how many among us could not afford to lose a few pounds around the middle?
The body manufactures DHEA naturally in the adrenal glands, although it declines as you age.
What are the risks of taking 7-KETO?
Based upon published clinical studies, there are no side effects for 7-Keto DHEA as compared with placebos during human clinical studies. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.
Interactions.
If you take any medicines regularly, talk to your doctor before you start using any DHEA supplements.
7-Keto is not recommended for children or for women who are pregnant or breastfeeding.
CLA – Conjugated linoleic acid
CLA helps reduce body fat deposits and improve immune function. It refers to a group of chemicals found in fatty acid / linoleic acid. Dairy products and beef are the major dietary sources, although are generally not present in levels that assist weight loss.
Conjugated linoleic acid is used for cancer, “hardening of the arteries” (atherosclerosis), obesity, weight loss caused by chronic disease, bodybuilding, and limiting food allergy reactions.
An average diet supplies 15-174 mg of conjugated linoleic acid daily. Fit America “Supreme” supplies 500 mgs.per dosage.